Pesquisa | Secretaria de Estado da Saúde

1.

Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

Saunders, Kevin O; Counts, James; Thakur, Bhishem; Stalls, Victoria; Edwards, Robert; Manne, Kartik; Lu, Xiaozhi; Mansouri, Katayoun; Chen, Yue; Parks, Rob; Barr, Maggie; Sutherland, Laura; Bal, Joena; Havill, Nicholas; Chen, Haiyan; Machiele, Emily; Jamieson, Nolan; Hora, Bhavna; Kopp, Megan; Janowska, Katarzyna; Anasti, Kara; Jiang, Chuancang; Van Itallie, Elizabeth; Venkatayogi, Sravani; Eaton, Amanda; Henderson, Rory; Barbosa, Christopher; Alam, S Munir; Santra, Sampa; Weissman, Drew; Moody, M Anthony; Cain, Derek W; Tam, Ying K; Lewis, Mark; Williams, Wilton B; Wiehe, Kevin; Montefiori, David C; Acharya, Priyamvada; Haynes, Barton F.

Cell ; 187(1): 79-94.e24, 2024 01 04.

Artigo Inglês | MEDLINE | ID: mdl-38181743

2.

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; Lu, Xiaozhi; Parks, Robert; Sutherland, Laura L; Oguin, Thomas H; McDanal, Charlene; Perez, Lautaro G; Mansouri, Katayoun; Gobeil, Sophie M C; Janowska, Katarzyna; Stalls, Victoria; Kopp, Megan; Cai, Fangping; Lee, Esther; Foulger, Andrew; Hernandez, Giovanna E; Sanzone, Aja; Tilahun, Kedamawit; Jiang, Chuancang; Tse, Longping V; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Cronin, Kenneth; Gee-Lai, Victoria; Deyton, Margaret; Barr, Maggie; Von Holle, Tarra; Macintyre, Andrew N; Stover, Erica; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Scobey, Trevor D; Rountree, Wes; Wang, Yunfei; Moody, M Anthony; Cain, Derek W; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Schmidt, Aaron G; Teng, I-Ting.

Cell ; 184(16): 4203-4219.e32, 2021 08 05.

Artigo Inglês | MEDLINE | ID: mdl-34242577

3.

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M.

Cell ; 184(11): 2955-2972.e25, 2021 05 27.

Artigo Inglês | MEDLINE | ID: mdl-34019795

4.

Structural diversity of the SARS-CoV-2 Omicron spike.

Gobeil, Sophie M-C; Henderson, Rory; Stalls, Victoria; Janowska, Katarzyna; Huang, Xiao; May, Aaron; Speakman, Micah; Beaudoin, Esther; Manne, Kartik; Li, Dapeng; Parks, Rob; Barr, Maggie; Deyton, Margaret; Martin, Mitchell; Mansouri, Katayoun; Edwards, Robert J; Eaton, Amanda; Montefiori, David C; Sempowski, Gregory D; Saunders, Kevin O; Wiehe, Kevin; Williams, Wilton; Korber, Bette; Haynes, Barton F; Acharya, Priyamvada.

Mol Cell ; 82(11): 2050-2068.e6, 2022 06 02.

Artigo Inglês | MEDLINE | ID: mdl-35447081

5.

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.

Saunders, Kevin O; Lee, Esther; Parks, Robert; Martinez, David R; Li, Dapeng; Chen, Haiyan; Edwards, Robert J; Gobeil, Sophie; Barr, Maggie; Mansouri, Katayoun; Alam, S Munir; Sutherland, Laura L; Cai, Fangping; Sanzone, Aja M; Berry, Madison; Manne, Kartik; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Kapingidza, Anyway B; Azoitei, Mihai; Tse, Longping V; Scobey, Trevor D; Spreng, Rachel L; Rountree, R Wes; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Tang, Juanjie; Oguin, Thomas H; Sempowski, Gregory D; Gagne, Matthew; Douek, Daniel C; Tomai, Mark A; Fox, Christopher B; Seder, Robert; Wiehe, Kevin; Weissman, Drew; Pardi, Norbert; Golding, Hana; Khurana, Surender; Acharya, Priyamvada; Andersen, Hanne; Lewis, Mark G; Moore, Ian N; Montefiori, David C; Baric, Ralph S; Haynes, Barton F.

Nature ; 594(7864): 553-559, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-33971664

6.

Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.

Wrapp, Daniel; Mu, Zekun; Thakur, Bhishem; Janowska, Katarzyna; Ajayi, Oluwatobi; Barr, Maggie; Parks, Robert; Mansouri, Katayoun; Edwards, Robert J; Hahn, Beatrice H; Acharya, Priyamvada; Saunders, Kevin O; Haynes, Barton F.

J Virol ; 97(1): e0167322, 2023 01 31.

Artigo Inglês | MEDLINE | ID: mdl-36633409

7.

Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design.

Manrique, Pedro D; Chakraborty, Srirupa; Henderson, Rory; Edwards, Robert J; Mansbach, Rachael; Nguyen, Kien; Stalls, Victoria; Saunders, Carrie; Mansouri, Katayoun; Acharya, Priyamvada; Korber, Bette; Gnanakaran, S.

iScience ; 26(1): 105855, 2023 Jan 20.

Artigo Inglês | MEDLINE | ID: mdl-36590900

8.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice.

Martinez, David R; Schafer, Alexandra; Gavitt, Tyler D; Mallory, Michael L; Lee, Esther; Catanzaro, Nicholas J; Chen, Haiyan; Gully, Kendra; Scobey, Trevor; Korategere, Pooja; Brown, Alecia; Smith, Lena; Parks, Rob; Barr, Maggie; Newman, Amanda; Bowman, Cindy; Powers, John M; Mansouri, Katayoun; Edwards, Robert J; Baric, Ralph S; Haynes, Barton F; Saunders, Kevin O.

bioRxiv ; 2023 May 23.

Artigo Inglês | MEDLINE | ID: mdl-37293083

9.

Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice.

Martinez, David R; Schäfer, Alexandra; Gavitt, Tyler D; Mallory, Michael L; Lee, Esther; Catanzaro, Nicholas J; Chen, Haiyan; Gully, Kendra; Scobey, Trevor; Korategere, Pooja; Brown, Alecia; Smith, Lena; Parks, Robert; Barr, Maggie; Newman, Amanda; Bowman, Cindy; Powers, John M; Soderblom, Erik J; Mansouri, Katayoun; Edwards, Robert J; Baric, Ralph S; Haynes, Barton F; Saunders, Kevin O.

Cell Rep ; 42(10): 113248, 2023 10 31.

Artigo Inglês | MEDLINE | ID: mdl-37858337

10.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes.

Kapingidza, Brenda; Marston, Daniel J; Harris, Caitlin; Wrapp, Daniel; Winters, Kaitlyn; Mielke, Dieter; Xiaozhi, Lu; Yin, Qi; Foulger, Andrew; Parks, Rob; Barr, Maggie; Newman, Amanda; Schäfer, Alexandra; Eaton, Amanda; Flores, Justine Mae; Harner, Austin; Cantazaro, Nicholas J; Mallory, Michael L; Mattocks, Melissa D; Beverly, Christopher; Rhodes, Brianna; Mansouri, Katayoun; Itallie, Elizabeth Van; Vure, Pranay; Manness, Brooke; Keyes, Taylor; Stanfield-Oakley, Sherry; Woods, Christopher W; Petzold, Elizabeth A; Walter, Emmanuel B; Wiehe, Kevin; Edwards, Robert J; Montefiori, David; Ferrari, Guido; Baric, Ralph; Cain, Derek W; Saunders, Kevin O; Haynes, Barton F; Azoitei, Mihai L.

bioRxiv ; 2023 Sep 17.

Artigo Inglês | MEDLINE | ID: mdl-36909627

11.

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes.

Kapingidza, A Brenda; Marston, Daniel J; Harris, Caitlin; Wrapp, Daniel; Winters, Kaitlyn; Mielke, Dieter; Xiaozhi, Lu; Yin, Qi; Foulger, Andrew; Parks, Rob; Barr, Maggie; Newman, Amanda; Schäfer, Alexandra; Eaton, Amanda; Flores, Justine Mae; Harner, Austin; Catanzaro, Nicholas J; Mallory, Michael L; Mattocks, Melissa D; Beverly, Christopher; Rhodes, Brianna; Mansouri, Katayoun; Van Itallie, Elizabeth; Vure, Pranay; Dunn, Brooke; Keyes, Taylor; Stanfield-Oakley, Sherry; Woods, Christopher W; Petzold, Elizabeth A; Walter, Emmanuel B; Wiehe, Kevin; Edwards, Robert J; Montefiori, David C; Ferrari, Guido; Baric, Ralph; Cain, Derek W; Saunders, Kevin O; Haynes, Barton F; Azoitei, Mihai L.

Nat Commun ; 14(1): 7897, 2023 Nov 30.

Artigo Inglês | MEDLINE | ID: mdl-38036525

12.

A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.

Bibollet-Ruche, Frederic; Russell, Ronnie M; Ding, Wenge; Liu, Weimin; Li, Yingying; Wagh, Kshitij; Wrapp, Daniel; Habib, Rumi; Skelly, Ashwin N; Roark, Ryan S; Sherrill-Mix, Scott; Wang, Shuyi; Rando, Juliette; Lindemuth, Emily; Cruickshank, Kendra; Park, Younghoon; Baum, Rachel; Carey, John W; Connell, Andrew Jesse; Li, Hui; Giorgi, Elena E; Song, Ge S; Ding, Shilei; Finzi, Andrés; Newman, Amanda; Hernandez, Giovanna E; Machiele, Emily; Cain, Derek W; Mansouri, Katayoun; Lewis, Mark G; Montefiori, David C; Wiehe, Kevin J; Alam, S Munir; Teng, I-Ting; Kwong, Peter D; Andrabi, Raiees; Verkoczy, Laurent; Burton, Dennis R; Korber, Bette T; Saunders, Kevin O; Haynes, Barton F; Edwards, Robert J; Shaw, George M; Hahn, Beatrice H.

mBio ; 14(1): e0337022, 2023 02 28.

Artigo Inglês | MEDLINE | ID: mdl-36629414

13.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates.

Malewana, R Dilshan; Stalls, Victoria; May, Aaron; Lu, Xiaozhi; Martinez, David R; Schäfer, Alexandra; Li, Dapeng; Barr, Maggie; Sutherland, Laura L; Lee, Esther; Parks, Robert; Beck, Whitney Edwards; Newman, Amanda; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; DeMarco, C Todd; Denny, Thomas N; Oguin, Thomas H; Rountree, Wes; Wang, Yunfei; Mansouri, Katayoun; Edwards, Robert J; Sempowski, Gregory D; Eaton, Amanda; Muramatsu, Hiromi; Henderson, Rory; Tam, Ying; Barbosa, Christopher; Tang, Juanjie; Cain, Derek W; Santra, Sampa; Moore, Ian N; Andersen, Hanne; Lewis, Mark G; Golding, Hana; Seder, Robert; Khurana, Surender; Montefiori, David C; Pardi, Norbert; Weissman, Drew; Baric, Ralph S; Acharya, Priyamvada; Haynes, Barton F; Saunders, Kevin O.

bioRxiv ; 2023 Dec 19.

Artigo Inglês | MEDLINE | ID: mdl-38187726

14.

Structural diversity of the SARS-CoV-2 Omicron spike.

Gobeil, Sophie M-C; Henderson, Rory; Stalls, Victoria; Janowska, Katarzyna; Huang, Xiao; May, Aaron; Speakman, Micah; Beaudoin, Esther; Manne, Kartik; Li, Dapeng; Parks, Rob; Barr, Maggie; Deyton, Margaret; Martin, Mitchell; Mansouri, Katayoun; Edwards, Robert J; Sempowski, Gregory D; Saunders, Kevin O; Wiehe, Kevin; Williams, Wilton; Korber, Bette; Haynes, Barton F; Acharya, Priyamvada.

bioRxiv ; 2022 Jan 26.

Artigo Inglês | MEDLINE | ID: mdl-35118469

15.

An antibody from single human V_H-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.

Luo, Sai; Zhang, Jun; Kreutzberger, Alex J B; Eaton, Amanda; Edwards, Robert J; Jing, Changbin; Dai, Hai-Qiang; Sempowski, Gregory D; Cronin, Kenneth; Parks, Robert; Ye, Adam Yongxin; Mansouri, Katayoun; Barr, Maggie; Pishesha, Novalia; Williams, Aimee Chapdelaine; Vieira Francisco, Lucas; Saminathan, Anand; Peng, Hanqin; Batra, Himanshu; Bellusci, Lorenza; Khurana, Surender; Alam, S Munir; Montefiori, David C; Saunders, Kevin O; Tian, Ming; Ploegh, Hidde; Kirchhausen, Tom; Chen, Bing; Haynes, Barton F; Alt, Frederick W.

Sci Immunol ; 7(76): eadd5446, 2022 10 28.

Artigo Inglês | MEDLINE | ID: mdl-35951767

16.

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.

Saunders, Kevin O; Edwards, Robert J; Tilahun, Kedamawit; Manne, Kartik; Lu, Xiaozhi; Cain, Derek W; Wiehe, Kevin; Williams, Wilton B; Mansouri, Katayoun; Hernandez, Giovanna E; Sutherland, Laura; Scearce, Richard; Parks, Robert; Barr, Maggie; DeMarco, Todd; Eater, Chloe M; Eaton, Amanda; Morton, Georgeanna; Mildenberg, Benjamin; Wang, Yunfei; Rountree, R Wes; Tomai, Mark A; Fox, Christopher B; Moody, M Anthony; Alam, S Munir; Santra, Sampa; Lewis, Mark G; Denny, Thomas N; Shaw, George M; Montefiori, David C; Acharya, Priyamvada; Haynes, Barton F.

Sci Transl Med ; 14(661): eabo5598, 2022 09 07.

Artigo Inglês | MEDLINE | ID: mdl-36070369

17.

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.

Mu, Zekun; Wiehe, Kevin; Saunders, Kevin O; Henderson, Rory; Cain, Derek W; Parks, Robert; Martik, Diana; Mansouri, Katayoun; Edwards, Robert J; Newman, Amanda; Lu, Xiaozhi; Xia, Shi-Mao; Eaton, Amanda; Bonsignori, Mattia; Montefiori, David; Han, Qifeng; Venkatayogi, Sravani; Evangelous, Tyler; Wang, Yunfei; Rountree, Wes; Korber, Bette; Wagh, Kshitij; Tam, Ying; Barbosa, Christopher; Alam, S Munir; Williams, Wilton B; Tian, Ming; Alt, Frederick W; Pardi, Norbert; Weissman, Drew; Haynes, Barton F.

Cell Rep ; 38(11): 110514, 2022 03 15.

Artigo Inglês | MEDLINE | ID: mdl-35294883

18.

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.

Martinez, David R; Schäfer, Alexandra; Gobeil, Sophie; Li, Dapeng; De la Cruz, Gabriela; Parks, Robert; Lu, Xiaozhi; Barr, Maggie; Stalls, Victoria; Janowska, Katarzyna; Beaudoin, Esther; Manne, Kartik; Mansouri, Katayoun; Edwards, Robert J; Cronin, Kenneth; Yount, Boyd; Anasti, Kara; Montgomery, Stephanie A; Tang, Juanjie; Golding, Hana; Shen, Shaunna; Zhou, Tongqing; Kwong, Peter D; Graham, Barney S; Mascola, John R; Montefiori, David C; Alam, S Munir; Sempowski, Gregory; Sempowski, Gregory D; Khurana, Surender; Wiehe, Kevin; Saunders, Kevin O; Acharya, Priyamvada; Haynes, Barton F; Baric, Ralph S.

Sci Transl Med ; 14(629): eabj7125, 2022 Jan 26.

Artigo Inglês | MEDLINE | ID: mdl-34726473

19.

Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.

Li, Dapeng; Martinez, David R; Schäfer, Alexandra; Chen, Haiyan; Barr, Maggie; Sutherland, Laura L; Lee, Esther; Parks, Robert; Mielke, Dieter; Edwards, Whitney; Newman, Amanda; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Gagne, Matthew; Douek, Daniel C; DeMarco, C Todd; Denny, Thomas N; Oguin, Thomas H; Brown, Alecia; Rountree, Wes; Wang, Yunfei; Mansouri, Katayoun; Edwards, Robert J; Ferrari, Guido; Sempowski, Gregory D; Eaton, Amanda; Tang, Juanjie; Cain, Derek W; Santra, Sampa; Pardi, Norbert; Weissman, Drew; Tomai, Mark A; Fox, Christopher B; Moore, Ian N; Andersen, Hanne; Lewis, Mark G; Golding, Hana; Seder, Robert; Khurana, Surender; Baric, Ralph S; Montefiori, David C; Saunders, Kevin O; Haynes, Barton F.

Nat Commun ; 13(1): 6309, 2022 10 23.

Artigo Inglês | MEDLINE | ID: mdl-36274085

20.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.

Li, Dapeng; Martinez, David R; Schäfer, Alexandra; Chen, Haiyan; Barr, Maggie; Sutherland, Laura L; Lee, Esther; Parks, Robert; Mielke, Dieter; Edwards, Whitney; Newman, Amanda; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Gagne, Matthew; Douek, Daniel C; DeMarco, C Todd; Denny, Thomas N; Oguin, Thomas H; Brown, Alecia; Rountree, Wes; Wang, Yunfei; Mansouri, Katayoun; Edwards, Robert J; Ferrari, Guido; Sempowski, Gregory D; Eaton, Amanda; Tang, Juanjie; Cain, Derek W; Santra, Sampa; Pardi, Norbert; Weissman, Drew; Tomai, Mark A; Fox, Christopher B; Moore, Ian N; Andersen, Hanne; Lewis, Mark G; Golding, Hana; Seder, Robert; Khurana, Surender; Baric, Ralph S; Montefiori, David C; Saunders, Kevin O; Haynes, Barton F.

bioRxiv ; 2022 Feb 14.

Artigo Inglês | MEDLINE | ID: mdl-35118474

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Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Structural diversity of the SARS-CoV-2 Omicron spike.

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.

Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.

Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice.

Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes.

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes.

A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates.

Structural diversity of the SARS-CoV-2 Omicron spike.

An antibody from single human V_H-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.

mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.

Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.